Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12323/3775
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DC Field | Value | Language |
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dc.contributor.author | Khalilova, Irada S. | - |
dc.contributor.author | Dickerhof, Nina | - |
dc.contributor.author | Mocatta, Tessa J. | - |
dc.contributor.author | Bhagra, Catriona J. | - |
dc.contributor.author | McClean, Dougal R. | - |
dc.contributor.author | Obinger, Christian | - |
dc.contributor.author | Kettle, Anthony J. | - |
dc.date.accessioned | 2018-05-07T07:05:11Z | - |
dc.date.available | 2018-05-07T07:05:11Z | - |
dc.date.issued | 2018-03-28 | - |
dc.identifier.citation | PLOS ONE | en |
dc.identifier.uri | http://hdl.handle.net/20.500.12323/3775 | - |
dc.description.abstract | Myeloperoxidase (MPO)-derived oxidants have emerged as a key contributor to tissue damage in inflammatory conditions such as cardiovascular disease. Pro-myeloperoxidase (pro-MPO), an enzymatically active precursor of myeloperoxidase (MPO), is known to be secreted from cultured bone marrow and promyelocytic leukemia cells, but evidence for the presence of pro-MPO in circulation is lacking. In the present study, we used a LC-MS/MS in addition to immunoblot analyses to show that pro-MPO is present in human blood plasma. Furthermore, we found that pro-MPO was more frequently detected in plasma from patients with myocardial infarction compared to plasma from control donors. Our study suggests that in addition to mature MPO, circulating pro-MPO may cause oxidative modifications of proteins thereby contributing to cardiovascular disease. | en |
dc.language.iso | en | en |
dc.title | A myeloperoxidase precursor, promyeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients | en |
dc.type | Article | en |
Appears in Collections: | Publications |
Files in This Item:
File | Description | Size | Format | |
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A myeloperoxidase precursor, pro-myeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients.pdf | 3.41 MB | Adobe PDF | View/Open |
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